Non-surgical treatment used to relieve knee pain due to osteoarthritis

VISCO-3 Sodium Hyaluronate is a solution made of highly purified, hyaluronan. Patients will receive a 2.5 mL injection of VISCO-3 Sodium Hyaluronate once a week for 3 weeks (a total of 3 injections).


  • Knee Injection


  • Early Intervention


  • Knee

In a clinical study patients treated with VISCO-3 Sodium Hyaluronate had a 52% reduction in their pain at week 12.1

Patients experienced


reduction in pain at week 12.1



Positive, Long Term Clinical Result1

  • In a clinical study VISCO-3 Sodium Hyaluronate  demonstrated  noninferior  pain relief compared to patients treated with competitor product.1  
  • There was no significant difference in the total Treatment-Emergent Adverse Events with VISCO-3 compared to competitor product.1

Safe and Effective Pain Relief for Knee OA1

  • One clinical trial revealed patients treated with VISCO-3 Sodium Hyaluronate had a 52% reduction in their pain at week 12.1

No Reports of Pseudoseptic Reactions

  • Pseudosepsis, or severe acute inflammatory response, is a rare but serious concern with some viscosupplement treatments. VISCO-3 had no reported incidences of pseudosepsis in clinical study.1



Indications For Use

VISCO-3 Sodium Hyaluronate is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics, e.g., acetaminophen.

Important Safety Information

Before using VISCO-3 Sodium Hyaluronate, ask your patients if they are allergic to hyaluronan products, or products from birds such as feathers, eggs, and poultry. Do not administer to patients with known hypersensitivity to sodium hyaluronate preparations. Use caution when injecting VISCO-3 Sodium Hyaluronate into patients who are allergic to avian proteins, feathers and egg products. VISCO-3 Sodium Hyaluronate is only for injection into the knee, performed by a doctor or other qualified health care professional. VISCO-3 Sodium Hyaluronate injection should not be used in the presence of a skin disease or infection around the area where the injection will be given. VISCO-3 Sodium Hyaluronate has not been tested to show pain relief in joints other than the knee and for conditions other than OA. VISCO-3 Sodium Hyaluronate has not been tested in patients who are pregnant, mothers who are nursing, or anyone under the age of 21. Strenuous or pro-longed weight-bearing activities after treatment are not recommended. The effectiveness of repeat treatment cycles of VISCO-3 Sodium Hyaluronate has not been established. The side effects most commonly seen after injection of VISCO-3 Sodium Hyaluronate in the clinical trial were knee pain, swelling, and/or fluid build-up around the knee. These reactions are generally mild and do not last long. Other conditions, including but not limited to skin redness and rash, knee stiffness were also reported. For complete instructions for use, see the package insert and visit

This material is intended for US Health Care Professionals.

VISCO-3™ is a trademark of Seikagaku Corporation.

Additional Information