All specimens are evaluated for white blood cell (WBC) count with differential via automated cell count (all counts >3,000 cells confirmed with manual count). If final reported WBC count is >3,000 cells/μL or neutrophil is >70%, specimens are reflexed to Synovasure Alpha Defensin for NSA (alpha defensin and lactate), Synovasure Microbial Identification and Fluid Culture.
Synovasure Alpha Defensin for NSA
Laboratory-developed test (LDT) for alpha defensin biomarker and lactate. The alpha defensin biomarker demonstrates high level of accuracy in identifying infection1* and is unaffected by:
- Prior Antibiotic Administration2,3
- History of Inflammatory Conditions2,4
- Type/Virulence of Organism2,5
**Validation and performance of alpha defensin is based on cases of PJI and has not been defined for NSA due to no comparative “Gold Standard” criterion.
Synovasure Microbial Identification
Novel, antigen bead-based test for early identification of potential infection causing organisms including:
- Staphylococcus species
- Enterococcus species
- Candida species
- C. acnes
Synovasure Microbial Identification is also capable of identifying more than 54% of culture-negative PJI specimens6.
Aerobic and anaerobic culture performed to aid in the diagnosis and treatment of infection.
All fluid cultures are held for seven (7) days.