Citra Labs, LLC
55 Messina Drive
Braintree, MA 02184 USA
Anticoagulant for Granulocytapheresis Procedures
triCitrasol Anticoagulant Sodium Citrate Concentrate, 46.7% Trisodium Citrate (30.5% free citrate ion), is a sterile, non-pyrogenic solution, used in granulocytapheresis procedures (granulocyte collection by apheresis).
Prior to performing granulocytapheresis, 30 mL of the triCitrasol Concentrate is aseptically added to 500 mL of the solution 6% Hydroxyethyl Starch (HES).
The final solution prevents the coagulation of blood by virtue of the citrate ion's ability to chelate ionized calcium present in the blood to form a non-ionized calcium-citrate complex. When the total dose of citrate ions is greater than the total amount of ionized calcium, clotting is prevented.
- Final solution prevents coagulation of blood through the citrate ion's ability to chelate ionized calcium present in the blood to form a non-ionized calcium-citrate complex. When total dose of citrate ions is greater than total amount of ionized calcium, clotting is prevented.
- triCitrasol Concentrate was approved by the US Food & Drug Adminsitration (FDA) in 2003
When Quality Matters
Zimmer Biomet develops and offers innovative blood rejuvenation solutions and citrate-based anticoagulants to support restoration of stored Red Blood Cells and blood processing with Autologous PRP Systems in production of Platelet-Rich Plasma (PRP).
Important Safety Information
triCitrasol Concentrate is an anticoagulant used in granulocytapheresis procedures.
Warnings and Contraindications
triCitrasol Concentrate is not for direct intravenous infusion.
triCitrasol Concentrate is a concentrated anticoagulant — dilute prior to use (see full prescribing information).
Citrate reactions or toxicity may occur with the infusion of blood
products containing citrate anticoagulant. The recipient of the
citrated blood product should be monitored for the signs and symptoms
of citrate toxicity which can begin with tingling sensations around
the mouth or in the extremities, followed by severe reactions
characterized by chills, stomach cramps, or pressure in the chest,
followed by more severe reactions characterized by hypotension and
possible cardiac arrhythmia. Citrate toxicity may occur more
frequently in patients that are hypothermic, have impaired liver or
renal function, or have low calcium levels because of an underlying
Citra Labs, LLC
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For product information, including indications, contraindications, warnings, precautions, potential adverse effects and patient counseling information, see the package insert or contact your local representative; search this website for additional product information. To obtain a copy of the current Instructions for Use (IFU) for full prescribing and risk information, please visit labeling.zimmerbiomet.com or call 1-800-348-2759, press 4 for 411 Technical Support.