If your knees ache, they have lots of company. Over 54 million Americans suffer from osteoarthritis.2

Osteoarthritis causes the lubricating properties of the synovial fluid in the knee joint to diminish, resulting in less protection and cushioning. In addition, osteoarthritis results in damage to the cartilage resulting in pain. You may feel pain climbing stairs, working in the garden, walking, bending your knees to sit and it may even keep you up at night.

Gel-One Hyaluronate injectable knee pain treatment addresses the pain caused by the diminishing lubricant in the joint and can provide significant relief for up to 6 months per treatment.1,3*

If you have knee pain due to osetoarthritis, Gel-One may provide relief so you can get back to doing what you love most. Talk to your doctor and find out if it’s time to stop imagining your life with significantly less knee pain and get back to living it with Gel-One.  

Find A Doctor

Fill out the form below to connect with a provider and start your journey toward greater mobility.

Gel-One® Hyaluronate Injectable Knee Pain Treatment

Hyaluronate injections have been available in the U.S. for a number of years, but only Gel-One Therapy delivers a complete treatment using a 3 mL non-steroid, natural and highly purified single injection to treat knee pain due to osteoarthritis. Gel-One is made from naturally occurring sodium hyaluronate and offers the following important benefits:

  • Pain relief with improved knee function for up to six months3†
  • Patient-friendly treatment requiring only one visit to your doctor for effective pain relief 3-5
  • A cost-effective treatment covered by most Medicare plans when administrated by a healthcare professional

Gel-One FAQs

*In a clinical study, a single injection for knee osteoarthritis demonstrated clinically important improvements in pain at 26 weeks in a subset of 152 patients. Clinically meaningful improvement was defined as >19.9 on a 100 mm scale.
†Gel-One® is a sterile, transparent, and viscoelastic hydrogel composed of cross-linked hyaluronate, a derivative of highly purified sodium hyaluronate (hyaluronan) extracted from chicken combs. Hyaluronan is a polysaccharide containing repeating disaccharide units of glucuronic acid and N-acetylglucosamine. In Gel-One®, strands of hyaluronan are bound to each other via dimers of cinnamic acid resulting in increased viscoelasticity. 
Indications for use & important safety information
Indications for use
Gel-One Hyaluronate is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to non-pharmacologic therapy, non-steroidal anti-inflammatory drugs (NSAIDs) or simple analgesics, like Acetaminophen.
Important safety information
Before using Gel-One Hyaluronate, tell your doctor if you are allergic to hyaluronan products, cinnamon, or products from birds such as feathers, eggs, and poultry. Gel-One Hyaluronate is only for injection into the knee, performed by a doctor or other qualified health care professional. You should not receive Gel-One Hyaluronate injection if you have a skin disease or infection around the area where the injection will be given. Gel-One Hyaluronate has not been tested to show pain relief in joints other than the knee and for conditions other than OA. Gel-One Hyaluronate has not been tested in patients who are pregnant, mothers who are nursing, or anyone under the age of 21. You should tell your doctor if you think you are pregnant or if you are nursing a child. Talk to your doctor before resuming strenuous or pro-longed weight-bearing activities after treatment. The effectiveness of repeat treatment cycles of Gel-One Hyaluronate has not been established. The side effects most commonly seen after injection of Gel-One Hyaluronate in the clinical trial were knee pain, swelling, and/or fluid build-up around the knee. These reactions are generally mild and do not last long. If any of these symptoms or signs appear after you are given Gel-One Hyaluronate or if you have any other problems, you should call your doctor. Ask your surgeon if you are a candidate for this procedure and discuss potential risks. For additional information, visit www.zimmerbiomet.com
This material is intended for U.S. patients.

All content herein is protected by copyright, trademarks and other intellectual property rights, as applicable, owned by or licensed to Zimmer Biomet or its affiliates unless otherwise indicated, and must not be redistributed, duplicated or disclosed, in whole or in part, without the express written consent of Zimmer Biomet.  

Zimmer Biomet does not practice medicine; only a surgeon can answer your questions regarding your individual symptoms, diagnosis and treatment.

Talk to your surgeon about whether joint replacement or another treatment is right for you and the risks of the procedure, including the risk of implant wear, loosening or failure, and pain, swelling and infection.

For printed information on joint replacement, call 1-800-447-5633.