- Biomet® OrthoPak® Non-invasive Bone
Growth Stimulator System (P850022/S017).
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King, J.B. A prospective, double-blind trial of electrical
capacitive coupling in the treatment of non-union of long bones.
J Bone Joint Surg Am, 1994. 76(6):820-6.*
- Data on
file at Zimmer Biomet, EBI, LLC
- Wang, Z., Clark, C.C. and
Brighton, C.T. Up-Regulation of Bone Morphogenetic Proteins in
Cultured Murine Bone Cells with Use of Specific Electric Fields.
J Bone Joint Surg Am, 2006. 88:1053-1065. *, **
- Brighton, C.T., Wang, W., Seldes, R., Zhang, G. and Pollack,
S.R. Signal transduction in electrically stimulated bone cells. J
Bone Joint Surg Am, 2001. 83A(10):1514-23.*,**
N., Lee, Y., Segina, D., Murray, H., Wilcox, T., Boulanger, L.
Economic burden of illness among US patients experiencing fracture
nonunion. Orthop Res and Reviews, 2013. 5:21-33.*
- Data on file at Zimmer Biomet, EBI, LLC, P&R17001
*FINANCIAL DISCLAIMER: In support of their research for or
preparation of this work, one or more of the authors may have received
financial remuneration from Zimmer Biomet, EBI, LLC or Biolectron,
**PRE-CLINICAL DISCLAIMER: Following non-invasive electrical
stimulation, increases in cell proliferation and multiple growth
factors have been observed in various pre-clinical in vitro
cellular and in vivo animal studies. Although not indicative of
human clinical results, these factors have been implicated in various
models of bone repair.
*** This study measured actual health care resource utilization and
did not assess clinical effectiveness or healing times.